-Amuc_2172 (acetyltransferase from A. muciniphila) inhibits tumorigenesis in colorectal cancer models by upregulating the production of heat-shock protein 70 (HSP70) and improving the immune response through increased CD8+ cytotoxic T lymphocyte activity [131]-The administration of Arg-Lys-His (Novel tripeptide derived from A. muciniphila) reduces inflammation symptoms through TLR4 inhibition [132]-The administration of A. muciniphila extracellular vesicles promotes gut barrier integrity [133]. The gene discussed is CD8A; the disease is colorectal cancer.