However, significant main effects of time were identified for resting heart rate (p = 0.002, ή2 = 0.18), systolic blood pressure (p < 0.001, ή2 = 0.38), diastolic blood pressure (p < 0.001, ή2 = 0.52), MAB (p < 0.001, ή2 = 0.52), HbA1c (p = 0.017, ή2 = 0.14), CRP (p < 0.001, ή2 = 0.22), hsCRP (p < 0.001, ή2 = 0.22), triglycerides (p = 0.024, ή2 = 0.11), HDL (p = 0.021, ή2 = 0.11), insulin (p = 0.033, ή2 = 0.10), HOMA-IR (p = 0.044, ή2 = 0.09), and the MetS z-score (p < 0.001, ή2 = 0.56). The gene discussed is INS; the disease is metabolic syndrome.