Moreover, a randomized trial that enrolled premenopausal participants demonstrated that both intermittent and continuous CR, during 6 months, not only resulted in weight loss of overweight and obese women, but also improved several cancer risk biomarkers (reduction in leptin, free androgen index, high sensitivity CRP, total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure, and increase in sex hormone binding globulin, IGFBP-1, and 2) [188]. This evidence concerns the gene IGFBP1 and cancer.