In another study, long-term enteral tube feeding with a diabetes-specific enteral formula—low in carbohydrates and enriched with monounsaturated fatty acids (MUFAs), fish oil, chromium, and antioxidants—was found to significantly decrease total insulin requirements and reduce the incidence of hypoglycemia in insulin-treated patients with T2DM and neurological disorders, compared to a standard diet. This evidence concerns the gene INS and type 2 diabetes mellitus.