Additionally, when an allergic reaction is initiated with a protein produced and secreted by eosinophils, the production amount of ECP that is proportional to the degree of eosinophil activity decreased by 0.12 ± 2.90 ng/mL in the placebo group and by 2.97 ± 6.86 ng/mL in the SBP group from baseline to 6 weeks of intake, exhibiting a significant decrease in the SBP group (p < 0.0001). Here, RNASE3 is linked to allergic disease.