PI3K/Akt/mTOR pathway not only serves as a critical regulator of eosinophil survival, activation, and degranulation but also controls eosinophil function and ECP release by regulating the balance between Th1/Th2 cells and cytokine secretion, thereby reducing tissue damage and alleviating symptoms of inflammatory and allergic diseases. This evidence concerns the gene AKT1 and allergic disease.