NLRP3 and diabetes mellitus: Recent research reported that Rb2 can regulate pyroptosis, improving insulin resistance (IR), by suppressing the expression of pyroptosis-related proteins, ASC, NLRP3, caspase-1, GSDMD, and IL-1β and declining the phosphorylation levels of p65 and IκBα both in vitro and in vivo, thus suggesting pyroptosis as a new promising therapeutic target for the diabetes treatment [63].