Baeckein E (BF-2) from Baeckea frutescens L. can be a beneficial bioactive compound for gout: in macrophages, it can suppress IL-1β secretion and cell pyroptosis as well as, in a gout mouse model, inhibit the activation of the NLRP3 inflammasome and reduce ankle swelling; its property of inhibiting NLRP3 inflammasome activation may be attributed to the MAPK/NF-κB pathways’ suppression [82]. This evidence concerns the gene NFKB1 and gout.