NLRP3 and metabolic dysfunction-associated steatotic liver disease: Moreover, vitamin D (VD) alleviated HFD-induced hepatic injury in rats both in vivo and in vitro in palmitic acid (PA)-treated or LPS-treated cells, and also reduced NLRP3 inflammasome activation and lipid accumulation in vivo and in vitro; the results also suggested that VD might attenuate non-alcoholic fatty liver disease (NAFLD) through pyroptosis because GSDMD-N fragment overexpression increased in cells with the activation of NLRP3 inflammasome in the VD group [66].