Epigallocatechin-3-gallate (EGCG), a polyphenol component of green tea, can improve glucose tolerance and alleviate NLRP3 inflammasome-mediated pyroptosis in a HFD-induced type 2 diabetes (T2D) mouse; further in vivo results were consistent with the in vitro data, which highlighted that EGCG inhibited pyroptosis by suppressing NLRP3 inflammasome, caspase-1 activation, and IL-1β secretion and blocked NLRP3-mediated ASC speck formation [59]. Here, CASP1 is linked to type 2 diabetes mellitus.