NLRP3 and bacterial infectious disease: and Vaniot (EOAA), a traditional medicine, can inhibit bacterial infection by regulating pyroptosis: specifically, EOAA blocked the assembly of NLRP3 inflammasome, the cleavage of pro-caspase-1 and pro-IL-1β, and the phosphorylation and translocation of NF-κB p65 in an MSU- and nigericin-induced bacterial infection cell model [40].