It has been shown that patients covering >90% of their I requirements with qualified iodized salt have higher methylation of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase (YWHAG) and brain-selective kinase 2 (BRSK2) with lower methylation of inhibitor of growth 4 (ING4) and interact with methylation levels of these genes, resulting in an increased risk of developing autoimmune thyroiditis [173]. This evidence concerns the gene BRSK2 and autoimmune thyroid disease.