Another study evaluated DNA methylation of genes related to the extrinsic apoptosis signaling pathway in autoimmune thyroiditis in areas with different I levels; an increase in death-associated protein kinase 1 (DAPK1) DNA methylation was observed in autoimmune thyroiditis patients, and a concentration-dependent effect of I on DAPK1 and tumor necrosis factor alpha-induced protein 8 (TNFAIP8) gene methylation was noted [176]. This evidence concerns the gene TNFAIP8 and autoimmune thyroid disease.