Screening of the expression levels of diverse CRC cell lines defined the KRASG13D- PIK3CAH1047R mutated HCT-116 cells [34] with nearly 1.5-fold and 5-fold SMYD2 and c-MET expression levels, respectively, compared to the non-tumorigenic human colon epithelial CCD 841 CoN cells (Figure 1). Here, SMYD2 is linked to colorectal carcinoma.