It is well established that 1,25(OH)2D3 is an effective modulator of B lymphocyte function and therefore improvement in vitamin D status through sunlight exposure may help activate B lymphocytes to produce antibodies, like antibodies to mutant p53 proteins, to fight skin cancers including NMSCs, which are often initiated by mutations of the p53 gene [150]. The gene discussed is TP53; the disease is skin neoplasm.