The same result was observed in periclinal studies designed by Wang et al., which revealed that CLL-1 CAR-T cells efficiently destroyed U937 and HL-60 cells as well as in vivo a xenogeneic model of AML translated by U937 cells but did not have the same effect on CLL-1-negative K562 cells [80]. This evidence concerns the gene CLEC12A and acute myeloid leukemia.