According to both guidelines, uncontrolled asthma and pregnancy are absolute contraindications for OIT, while active severe atopic dermatitis, pre-existing EoE, heart disease, and the use of beta-blockers or angiotensin-converting enzyme (ACE) inhibitors are relative contraindications based on clinical judgement, provider expertise, and shared decision-making [2, 49]. This evidence concerns the gene ACE and heart disorder.