More importantly, animals treated with anti-PD-1 and TIGIT antibodies showed an increase in immune-infiltrated lymphocytes per tumour weight as well as the number of CD107a + CD8 + T cells and their ratio to CD4 + /Foxp3 + regulatory T cells within the tumour (Supplementary Fig. 3, 4). The gene discussed is LAMP1; the disease is neoplasm.