NQO1 and colorectal carcinoma: Single variable analysis reinforced this result, revealing a significant correlation between overall survival in patients with CRC and factors such as lymph node metastasis (P = 0.001), clinical stage of the disease (P = 0.029), and NQO1 expression status (P = 0.000), thus supporting the potential of NQO1 as a strong prognostic indicator of CRC.