ColX modules also exhibited significant overrepresentation and/or differential activity of transcription factor (TF) networks crucial to numerous developmental pathways known to play a role in cancer aggressiveness and metastasis (Notch, Wnt, and Hedgehog signaling), including FOXH1, SOX15, and several PRDM gene family members [109–114]. The gene discussed is FOXH1; the disease is cancer.