RUNX2 and familial pancreatic carcinoma: While both gender-specific pancreatic cancer modules were enriched for numerous GO terms and Reactome pathways which were also significant in their combined analysis (e.g., various ECM terms, “ossification,” “cartilage development,” and several terms related to chondroitin sulfate metabolism), the male PAAD ColX module was additionally enriched for the GO terms “bone morphogenesis,” “Wnt signaling,” and “epithelial to mesenchymal transition,” as well as Reactome pathways relating to RUNX2 signaling and platelet responses (Table S3D, S3I).