In particular, SIX1 has been shown to induce EMT and metastasis in breast tumors [79] and implicated in TGF-β regulation of collagen deposition leading to hampered immune infiltration and survival in cancer [80], while PRDM5 has been linked to pro-metastatic production of collagen in breast cancer [81]. This evidence concerns the gene TGFB1 and breast neoplasm.