HOXC8 and breast carcinoma: NUP214 is of particular interest as its varied fusion products have been implicated as drivers of breast cancer (via fusion with NOTCH) [85] and leukemogenesis (via aberrant activation of HOX genes) [86]; similarly, HOXC8 co-modularizes with COL10A1 in BRCA (Table S2A) and Hoxa3 has been shown to be upregulated alongside Col10a1 and implicated in OA progression in hypertrophic mouse chondrocytes [87].