Targets of MCM5, a crucial component of the MCM replicative helicase complex which has been linked to negative prognosis in breast cancer and implicated as a marker of pancreatic malignancy, were the most significantly upregulated in both BRCA and PAAD high-ColX module tumors, an effect which was also observed in the pancreatic gender-specific analysis. This evidence concerns the gene MCM5 and breast cancer.