The ColX modules include numerous matrisome genes previously implicated in tumor progression and metastasis, including ECM regulators CTSB, LOXL2, and SERPINF1, and ECM glycoprotein SNED1, which have been reported as markers of highly metastatic breast carcinomas that promote tumor invasiveness across a variety of models [68] (Table S2A). Here, CTSB is linked to breast carcinoma.