A compelling piece of evidence for this common developmental feature is the fact that the Wnt family gene WNT2 emerged as a ColX module gene in both BRCA and PAAD (Table S2A) as well as a specific marker of BMSCs (Table S6); the Wnt signaling cascade is heavily implicated in joint degeneration and OA pathogenesis [125], and WNT2 has been established as a highly-expressed gene in breast cancer as well as a pro-metastatic activator in pancreatic cancer [126, 127]. Here, WNT2 is linked to pancreatic adenocarcinoma.