ZNF454 and cancer: Significant downregulation in high-ColX module tumors was also observed for targets of numerous zinc-finger TFs (ZNF302, ZNF211, ZFP37, ZNF23, ZNF454, ZNF774, ZNF419, and ZNF416) associated with TRIM28, a pro-tumorigenic driver of EMT which stabilizes TWIST1 to promote cancer cell invasion and migration [88].