Our observed activation of antigen-presenting CAFs in pancreatic cancer is of particular interest, as prior studies in pancreatic cancer have shown that this CAF subtype interacts significantly with tumor-infiltrating T cells and TAMs through MHC II expression which induces naive CD4+ T cells to differentiate into regulatory T cells, thereby contributing to immune evasion [120, 121]. This evidence concerns the gene CD4 and familial pancreatic carcinoma.