Genes coding for various CXC chemokines, inflammatory cytokines, and matrix metalloproteinases were identified as EMT-associated markers in OA-MSCs (CXCL1, CXCL6, CXCL8, IL6, MMP1, PTX3, TNFAIP3) (Table S6); while these were not specifically co-modularized with COL10A1 in tumors, several related genes in both the CXC and MMP families are present in the ColX modules (pro-metastatic CXCL12 in BRCA, pro-angiogenic MMP2 in both BRCA and PAAD, and related MMPs 2, 3, and 14 in male PAAD) (Table S2A; Figures S2E, S2F). The gene discussed is CXCL12; the disease is invasive breast carcinoma.