Using a multivariate Cox proportional hazards model to assess overall survival risk, increased COL10A1 expression was found to be significantly associated with negative prognosis (+ 17% risk per standard deviation in breast cancer, p.adj = 0.048; + 31% risk per standard deviation in pancreatic cancer, p.adj = 0.030) (Fig. 4A). The gene discussed is COL10A1; the disease is breast cancer.