Although COL10A1 has been reported to be expressed by pancreatic cancer cells directly [73], we observed that ColXα1 is most strongly detected in the stromal region of PAAD tumors and is absent in normal tissue (Fig. 1B), suggesting that it more likely serves as a marker for infiltration of fibroblasts and subsequent induction of an immunosuppressive microenvironment. This evidence concerns the gene COL10A1 and familial pancreatic carcinoma.