At the molecular level, the expression of Il4, Il17a, and Il33, but not that of Tslp, Ccl20 or Ccl27a, was dramatically lower in the skin lesions of the IL-1R antibody-treated SSKO mice than in those of their IgG-treated SSKO littermates (Fig. 6S, Supplementary Fig. S9L). The gene discussed is IL4; the disease is neoplasm.