In both BM samples from HDs and CP-CML patients (panels E, F of Fig. S4), we could clearly identify CD45RA-CD34-IRF8-MPO+CD66b-DEFA-, CD45RA+CD34-IRF8-MPO+CD66b-DEFA+, and CD45RA-CD34-IRF8-MPO+CD66b-DEFA+ cells that, according to our flow cytometry and ICC data (Figs. 1A, 5C, D), likely correspond to SSCloCD45RA-NCP4s (light blue asterisks in panels F, G of Fig. 7), SSChiCD45RA-NCP5s (green asterisks in panels F of Fig. 7) and SSChiCD45RA-NCP6s (red asterisks in panels F, G of Fig. 7). Here, IRF8 is linked to intrahepatic cholangiocarcinoma.