hMSH2-Ab-γδ TCR-T cells exhibited stronger cytotoxicity against various tumor cell lines with much higher levels of ectopic surface hMSH2 expression, including SW480, NCI-H446, U87-MG, GLC-82, Caco2 and HT-29 cells (Fig. 4d, Supplementary Data Fig. 12a, Supplementary Data Fig. 13a). This evidence concerns the gene MSH2 and neoplasm.