Analysis of the PAAD_GSE148673 dataset revealed that ACOT8 was enriched in epithelial and malignant cells in PDAC tissues (Fig. 1d), and analysis of ACOT8 expression levels in the TCGA database revealed significantly higher ACOT8 expression levels in cancer tissues than in paracancerous tissues (Fig. 1e), which further suggests that ACOT8 may be involved in PDAC development. The gene discussed is ACOT8; the disease is cancer.