Weill–Marchesani syndrome 2 (WMS2; OMIM #698328), characterized by short stature and brachydactyly, is another rare AD disorder (prevalence of 1 in 100,000) caused by mutations in FBN1. El is one of the main symptoms of WMS2 [8]. The gene discussed is FBN1; the disease is Weill-Marchesani syndrome 2, dominant.