Somatostatin secretion has also been shown to be reduced in both diabetic ob/ob and high fat diet-fed mice (Kellard et al, 2020; van der Meulen et al, 2015), and a recent study showed reduced numbers of ghrelin-secreting cells and reduced circulating levels of ghrelin in human type-2 diabetes (Lindqvist et al, 2020), which may explain the impaired somatostatin release. Here, GHRL is linked to type 2 diabetes mellitus.