Indeed, in the PRP130 GEMM, we also found that both SOX1 (marking NE cells) and MCT4 (marking non-NE cells) were completely absent in PNEC and NEB (PNEC/NEB) but appeared in mSCLC tumours (Fig. 4j), and they were expressed by completely distinct subpopulations in both mSCLC and hSCLC tumours (Fig. 4k and Extended Data Fig. 8j). This evidence concerns the gene SOX1 and neoplasm.