Coincidentally, SCLC NE-preferential vulnerability has been identified from a previous cross-cancer type CRISPR screen42, in which three out of the eight top candidate genes encode ETC complex proteins: Ndufa1, Sdha and Sdhb (Fig. 3d), rendering ETC the most prominent hallmark of SCLC NE cell-preferential vulnerability (Extended Data Fig. 7b). Here, SDHA is linked to small cell lung carcinoma.