We did not observe the effect by Yaa locus on the ratio of immune cells but we found dramatically increased populations of macrophages (CD45+ CD11b+ F4/80+) and pDCs (CD11clo/int Ly6Chi PDCA-1+ B220+) in MNV infected spleens, compared to spleen without infections, in particular after the mucosal infection (Supplementary Fig. 11 and 12a, b). Here, PTPRC is linked to infection.