KDR and Hyperglycemia: The relevance of VEGFR-2 mediated signaling in the neuroprotective properties of VEGF-A was confirmed in Schwann cells [64] and in dorsal root ganglion neurons injured by hyperglycemia [65] or by neurotoxic drug (paclitaxel) [66], through induction of Heat Shock Protein 90 deacetylation and increase of Bcl-2 [66].