VEGFR-2 is known for its contribution in physiological angiogenesis [17] and in neuroprotective pathways [[18], [19], [20], [21]] while VEGFR-1 has been associated with pathological processes such as inflammation, tumor-associated angiogenesis [22] and tumor progression, being up-regulated in a variety of cancers [23]. The gene discussed is FLT1; the disease is cancer.