Moreover, KDM6B induces the expression of the mesenchymal genes SNAI1 and CXCR4, which contribute to the metastasis of breast and gastric cancers (Liu et al., 2022, Ramadoss et al., 2012), and its expression is associated with poor outcomes in patients with gastric cancer (Xu et al., 2019). Here, CXCR4 is linked to gastric cancer.