However, the IVM assays showed that oocytes isolated from Hdac3OE mice underwent normal spontaneous maturation as those controls did, as were shown by the GVBD rates (Fig. S1B), indicating that the pathogenic mechanism of HDAC3 presence in ovulatory follicular GCs leading to female infertility is blocking LH-induced oocyte maturation and ovulation. This evidence concerns the gene PLOD1 and female infertility.