When quantified using Fiji,19 the expression signals of HSP90B1 and CANX obtained by immunohistochemistry (IHC) were significantly increased in both uninvolved (P < 0.001, P < 0.01) and involved skin in AD (P < 0.001, P < 0.01), respectively, compared with the normal control (Figure 2(b); Table S2). The gene discussed is CANX; the disease is Alzheimer disease.