APLP2 and Alzheimer disease: In our study, multiple pathways suggestive of intracellular abnormalities in AD (DAMPs S100A7, A8, A9, and NMI), MHC class I-related genes (APLP2, B2M, HSP90B1, CANX) and ERAD (MLEC)18 were enhanced (Figure 2(a)).