For inflammatory diseases, compound 54, reported by Jiang et al. 54to selectively inhibit HSP90B1, has also been found to be effective in a mouse model of ulcerative colitis. HSP90B1 expression was also upregulated in the present microarray analysis; thus, HSP90B1 may be a therapeutic target in AD. The gene discussed is HSP90B1; the disease is Alzheimer disease.