CRP and chronic obstructive pulmonary disease: However, despite the discovery of many positive clinical and immunological effects of the influenza vaccination, investigations of immunization effect on the cytokine profile, C-reactive protein (CRP), which characterize the inflammatory process in patients with diseases of the bronchopulmonary system, as well as the relationship with clinical and functional parameters in patients with asthma and COPD vaccinated against influenza are currently limited.