Notably, defective endosomal EGFR signaling was sufficient to induce deleterious consequences for the health of photoreceptor cells, which showed reduction in POS compared with native rods (Figure 7g), similar to the pathogenesis of macular degeneration (Borrelli et al., 2020; Kaur and Lakkaraju, 2018). This evidence concerns the gene EGFR and macular degeneration.