Mutations in both hnRNPU and SYNCRIP are linked to intellectual disability (Lelieveld et al., 2016; Balasubramanian, 2022; Bramswig et al., 2017) and neurodevelopmental disorders (Gillentine et al., 2021; Wang et al., 2020), and were the two top candidates in an IBM Watson-based study to identify RBPs altered in amyotrophic lateral sclerosis (ALS) (Bakkar et al., 2018). The gene discussed is SYNCRIP; the disease is amyotrophic lateral sclerosis.