GPT and Fever: Treatment-emergent SAE were observed in 13 patients (28.9%; Table 2), with the following SAE occurring in two patients (4.4%) each: pyrexia resulting in hospitalization, one each at 480 mg (grade 2, not related to AZD8701) and 720 mg (grade 1, related to AZD8701); grade 3 increased ALT related to AZD8701 treatment, both at 960 mg; and grade 3 pulmonary embolism not related to AZD8701 treatment, both at 720 mg.