GPT and asthenia: The most frequently observed TEAE across all dose cohorts were anemia (n = 18, 40.0%), fatigue (n = 16, 35.6%), diarrhea (n = 15, 33.3%), asthenia (n = 14, 31.1%), pyrexia (n = 12, 26.7%), increased alanine aminotransferase (ALT; n = 11, 24.4%), increased aspartate aminotransferase (AST), and increased blood creatinine (n = 10, 22.2%, each; Supplementary Table S3).