Overproduction of IL-1β is linked to pathophysiological alterations in diseases such as rheumatoid arthritis, neuropathic pain, inflammatory bowel disease, osteoarthritis, vascular disease, multiple sclerosis, and Alzheimer’s disease (Dinarello 1996, 2004; Braddock and Quinn 2004). The gene discussed is IL1B; the disease is osteoarthritis.