TNF and Lyme disease: In Lyme disease, caused by Borrelia burgdorferi, which can suppress TH1 responses to persist in the host, cimetidine may enhance TH1-associated cytokines (IL-12, TNF-α, IFN-γ) and suppress TH2 cytokines (IL-10), restoring immune balance (Embers et al. 2004).