In a recent study, Almacellas Barbanoj et al. used the CaMKII promoter to express EKC in an AAV9 vector used to treat frontal lobe focal cortical dysplasia in a mouse model (in utero electroporation of frontal lobe NPCs with a constitutively active human Ras homolog enriched in brain (RHEB) plasmid). Here, RHEB is linked to cerebral cortical dysplasia.