In this study, we investigated, for the first time, the effect of a neutralizing anti-IL-15 monoclonal antibody (aIL-15) in preventing epithelial damage in the intestinal mucosa of untreated CeD patients by analyzing the expression of perforin, CD95/Fas and HLA-E by immunohistochemistry. Here, PRF1 is linked to cranioectodermal dysplasia.