We also demonstrated that anti-IL-15, in intestinal mucosa from untreated CeD patients, causes downregulation of molecules that mediate the killing of enterocytes by activated CD8+ T IELs, such as Fas and HLA-E, compared with biopsy specimens cultured without the aIL-15 antibody. The gene discussed is CD8A; the disease is cranioectodermal dysplasia.