MAPT and Alzheimer disease: Among them, Flannery and Trushina [9] found giant mitochondria they called mitochondria-on-a-string (MOAS) in the hippocampus and cortical brain of AD patients; García-Escudero and collaborators [40] reported data from sporadic AD patients indicating the presence of elongated and interconnected mitochondria in fibroblasts [40,51] and fragmented mitochondria in neurons, with predominant localization in the perinuclear space, probably as a result of mitochondrial fission protein FIS167 overexpression and a concurrent involvement of tau proteins [16,40].