MAPT and dementia: Indeed, older age is the strongest risk factor for dementia [10,11] and is mainly responsible for all dementia conditions is Alzheimer’s disease (AD), a progressive neurodegenerative disorder [12], which is distinguished from the others with the presence of two neuropathological markers, the β-amyloid (Aβ) plaques and the tau neurofibrillary tangles, which are detectable in post-mortem brains [12].