For example, lncRNA HOTTIP mediates HOXA9 expression to enhance Wnt/β–catenin pathway activation by binding to WDR5 in pancreatic cancer stem cells (PCSCs), leading to upregulated expression of CSC markers (CD44, CD133, and ALDH1) as well as stem-associated factors (SOX2, OCT4, LIN28, and NANOG) [106]. Here, SOX2 is linked to familial pancreatic carcinoma.