Linc-DYNC2H1-4 acts as a ceRNA for miR-145 and facilitates the expression of its target genes, including ZEB1, a key regulator of EMT, as well as CSC markers SOX2, OCT4, NANOG, and Lin28, thereby promoting EMT and CSC activity in pancreatic cancer [107]. Here, SOX2 is linked to familial pancreatic carcinoma.