Mechanistically, INHEG promotes the interaction between NOP58 and TAF15, a SUMO2 E3 ligase, leading to the SUMOylating of NOP58, which is crucial for snoRNP complex formation and rRNA 2’-O-methylation, leading to elevated translation of oncogenic proteins in glioma [8] (Figure 2B). The gene discussed is NOP58; the disease is central nervous system cancer.