For example, Linc00319 upregulates the expression of high-mobility group box3 (HMGB3) by recruiting E2F transcription factor 1 (E2F1) in laryngeal squamous cell carcinoma (LSCC) [73], while lncRNA408 induces chibby1 (CBY1) downregulation in breast cancer stem cells (BCSCs) by mediating the transcription factor SP3 to its promoter, thereby suppressing CBY1 transcription [4]. Here, E2F1 is linked to breast cancer.