The EMT/MET plasticity of tumor cells is tightly controlled by a core set of EMT transcription factors (EMT-TFs), which constitute three distinct protein families: the SNAIL family of zinc-finger TFs including SNAI1 (also known as SNAIL or SNAIL1) and SNAI2 (also known as SLUG), the zinc-finger E-box-binding homeobox TFs including ZEB1 and ZEB2, and the basic helix-loop-helix TFs including TWIST1 and TWIST2 [42]. This evidence concerns the gene SNAI2 and neoplasm.