For example, lncRNA HOTTIP mediates HOXA9 expression to enhance Wnt/β–catenin pathway activation by binding to WDR5 in pancreatic cancer stem cells (PCSCs), leading to upregulated expression of CSC markers (CD44, CD133, and ALDH1) as well as stem-associated factors (SOX2, OCT4, LIN28, and NANOG) [106]. This evidence concerns the gene LIN28A and familial pancreatic carcinoma.