In contrast to TGFβ-induced lncRNAs such as LITATS1 and LETS1, lncRNA SMASR is downregulated by TGFβ/Smad2/3 signaling, and the expression of SMASR in turn inhibits TGFβR1 expression by interacting with Smad2/3, thus suppressing TGFβ-induced EMT, as well as cellular migration and invasion in lung cancer [124]. The gene discussed is TGFBR1; the disease is lung cancer.