In a PCLS from naphthalene-injured INKBRITE (p16Ink4a) lungs with senescent characteristics, the inhibition of HSP90 with XL888 eliminated senescent fibroblasts with the p16INK4a+, ACTA2+, and COL1+ markers in a bleomycin lung fibrosis model. Here, CDKN2A is linked to pulmonary fibrosis.