Finally, IPF lung fibroblasts release pro-apoptotic molecules, such as pro-caspase 3, cytochrome C, HIF-1α, HTRA2-OMI, and TNFR1, that reduce migration (via RhoA/ROCK) and induce apoptosis in T cells. The gene discussed is HTRA2; the disease is idiopathic pulmonary fibrosis.