ACSL4 and idiopathic pulmonary fibrosis: On the other hand, a recent study of exosomes from IPF patients showed that one of the effects of antifibrotic drugs is the return to normal FASN (fatty acid synthase) and ACSL4 (acyl-CoA-synthetase long-chain family member 4) levels, the mRNAs of which were downregulated due to miR-143-5p and miR-342-5p.