Active PARP1 further reduced NAD+ and anti-MASLD SIRT1 and boosted the function of pro-mitochondrial mitophagy PTEN-induced kinase 1 (PINK1) in an apolipoprotein E knockout (ApoE−/−) mouse model of MASLD fed with a WD [129]. Here, APOE is linked to metabolic dysfunction-associated steatotic liver disease.