CDH1 and ductal breast carcinoma in situ: We have shown that the overexpression of Sprouty4 in the IDC cell line MCF10.CA1d suppresses ERK/MAPK phosphorylation, reverses their aggressive phenotype via the restoration of E-cadherin, reduces invasion, and reduces cellular proteolysis [177], a factor in the transition of DCIS to IDC [184].