Immunohistochemical analysis of stromal tissues showed that fewer immune cells were present in DCIS with stromal changes compared to those without, and that intraductal clusters of differentiation (CD)8+ lymphocytes were most common in human epidermal growth factor receptor-2 positive (HER2+)/ER+ DCIS compared to other subtypes [90]. Here, ERBB2 is linked to ductal breast carcinoma in situ.