This screening and subsequent analysis resulted in three studies that delineated the roles of Aldehyde Dehydrogenase Isoform 5A1 (ALDH5A1) [176], Rap1Gap (RAP1GAP) [170], and Sprouty4 (SPRY4) [177] in DCIS progression. This evidence concerns the gene SPRY4 and ductal breast carcinoma in situ.