TRIM46 and ovarian cancer: Volcano plots revealed significant gene expression changes between ovarian cancer cells treated with MQ-CM and those exposed to plain medium (Figure 1A and Supplementary Table S2), with the top upregulated and downregulated genes displayed in Figure 1B. Among the upregulated genes, TRIM46, a member of the tripartite motif (TRIM) protein family implicated in cancer development and progression [8], was notably up-regulated in macrophage-stimulated ovarian cancer cells.