The enhanced Hsp90 presence in tumor cells promotes DYRK3 LLPS, which then increases the activity of p62 by phosphorylating it at the Ser-207 and Thr-269 residues, to in turn phosphorylate the mTOR1 protein via TRAF6 phosphorylation as an intermediary [183]. Here, HSP90AB1 is linked to neoplasm.