AKT1 and acute myeloid leukemia: In acute myelogenous leukemia (AML), the epichaperome formation stabilizes and maintains the activity of oncogenic kinases and the mutant p53 transcriptional factor, consequently promoting PI3K/Akt/mTOR, MAPK/ERK, and STAT3, c-MYC, as well as HIF-1α signaling pathways [132].