Maintains the cell surface membrane expression levels of CD24 by stabilizing it to promote sustained STAT3 phosphorylation, which promotes VEGF production and stimulates angiogenesis in colorectal cancer.Hsp90 inhibition, in addition to STAT3, downregulates TWIST1 gene transcription that slows tumor growth and promotes chemoresistance. The gene discussed is STAT3; the disease is neoplasm.