Moreover, patients with an unclassified myeloproliferative neoplasm harboring PML-SYK gene fusion show an upregulation of phospho-SYK, phospho-STAT5, phospho-ERK1/2, and phospho-S6 genes that drives a hyperactivated signal modulated by the epichaperome [89]. Here, SYK is linked to myeloproliferative neoplasm.