This study shows striking parallels between organelle damage caused by the NMDAR/TRPM4 signaling complex and organelle damage observed in mouse models of neurodegenerative diseases and in post mortem brain tissue from patients with Alzheimer’s disease [27,28,29,30], ALS [31,32,33], Huntington’s disease [34,35,36], Parkinson’s disease [37,38], glaucoma [39], retinal degeneration [40], and stroke [41,42]. This evidence concerns the gene TRPM4 and early-onset autosomal dominant Alzheimer disease.