However, in SCD and other hemolytic disease conditions, due to persistent hemolysis, heme is accumulated in organs, causing significant upregulation of HO-1, which acts as an inducer of Cyp3A11, and HO-1 and Cyp3A11 together inhibit tissue accumulation of xenobiotics by potentially inducing the NADPH driven antioxidative stress mechanism. Here, HMOX1 is linked to Schnyder corneal dystrophy.