In addition, it should be considered that JNK2 is considered a tumor suppressor and has been shown to have an opposite role to that of JNK1 in tumor tissue [40].The finding of a significant correlation between SHARPIN and STING expression and MGMT expression in glioblastoma is of particular interest since MGMT protein is a marker of resistance to TMZ therapy [7,41]. This evidence concerns the gene SHARPIN and neoplasm.