In addition to the critical role of the NCC transporter in tBS, in a pre-eclampsia mouse model induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), increased renal expression of HIF1α was observed, accompanied by elevated levels of total and phosphorylated NCC, contributing to hypertension [16]. The gene discussed is SLC12A3; the disease is hypertensive disorder.