Although the specific roles of these gene changes remain unclear, partly due to the animals being euthanized at a single end point (1 year of age), several speculative insights can be drawn: H2bc24, Fos, Cd74, Tent5a, Traip, and Sap25 may contribute to maintaining hippocampal genome stability, transcriptional activity, neuroinflammation, glioma progression, and immune responses at later stages of animal life [19,20,21,22,23]. The gene discussed is TENT5A; the disease is central nervous system cancer.