A significant reduction in hyperphosphorylated tau levels was observed in the hippocampus, CA1 cell body region, and dentate gyrus in control tauopathy models compared to tauopathy models in which the components of the NLRP3 inflammasome were disrupted (Tau22/Asc−/− and Tau22/Nlrp3−/− mice); these outcomes also led to the recovery of spatial memory deficits. This evidence concerns the gene NLRP3 and tauopathy.