ATG7 and colitis: Autophagy has been studied in murine models, where autophagy was studied in ATG7-deficient and wild-type mice; ATG7 is a core molecule involved in the autophagy process in mammals and in the administration of thiopurine-ameliorated colitis in wild-type but not in ATG7-deficient mice, demonstrating that the effect on inflammation control its due to autophagy.