MAPT and Alzheimer disease: Tukey post hoc tests revealed that, compared with CN, tau deposition was significantly increased in AD subjects in the temporal cortex (p = 0.003), hippocampus (p = 0.008), and MTL (p = 0.002), and tau deposition was also significantly increased in Aβ-positive MCI compared with CN in MTL (p = 0.041, Table 2, Figure 2A–C).