Serving as a substrate-recognition subunit of SCF E3 ligase, FBXO45 and other F-box family members have been demonstrated to be involved in biological and pathological processes, ranging from cancinogenesis (41, –, 43) to nervous system (20, –, 22) and psychiatric disorders (44), and their potential as therapeutic targets has been underscored (45). Here, FBXO45 is linked to psychiatric disorder.